Of Mice and Methylation

Psychotropic drugs (SRIs) are often used to treat maternal depression during depression. These drugs can affect the infant and perhaps have negative long-term consequences.  Translational research is often used to study mechanisms that cannot be studied in humans. In this study we are developing a mouse model of prenatal SSRI exposure to compare with human infant data to study epigenetic mechanisms that may be responsible for the effects of these drugs on newborn neurobehavior. Primary Investigators: Kevin Bath PhD, Barry Lester PhD.